Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parent
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Abstract Arabidopsis thaliana mapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of theNOP2A candidate gene located inside the largest effect QTL and of two other ribosomal genesRPL5A andRPL5B establish a shorter telomere length set point than wild type. These findings indicate that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways promote telomere elongation. -
Campitelli, Brandon E. ; Razzaque, Samsad ; Barbero, Borja ; Abdulkina, Liliia R. ; Hall, Mitchell H. ; Shippen, Dorothy E. ; Juenger, Thomas E. ; Shakirov, Eugene V. ( , New Phytologist)
Summary Telomere length has been implicated in the organismal response to stress, but the underlying mechanisms are unknown.
Here we examine the impact of telomere length changes on the responses to three contrasting abiotic environments in Arabidopsis, and measure 32 fitness, developmental, physiological and leaf‐level anatomical traits.
We report that telomere length in wild‐type and short‐telomere mutants is resistant to abiotic stress, while the elongated telomeres in
ku70 mutants are more plastic. We detected significant pleiotropic effects of telomere length on flowering time and key leaf physiological and anatomical traits. Furthermore, our data reveal a significant genotype by environment (G × E) interaction for reproductive fitness, with the benefits and costs to performance depending on the growth conditions.These results imply that life‐history trade‐offs between flowering time and reproductive fitness are impacted by telomere length variation. We postulate that telomere length in plants is subject to natural selection imposed by different environments.